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Z-TOX

APPLICATION

The Z-Tox test is designed to determine the acute toxicity of chemicals in just 5 days. Its protocol is described in OECD Guideline 236 and is useful for assessing the safety of compounds in preclinical research.

The use of fish embryos allows for high-throughput screening, providing predictability similar to adult fish and reducing animal testing.

DESCRIPTION

Incubation of embryos with different concentrations of the substance of interest spaced by a constant factor between 3 and 96 hours post-fertilization (hpf).

The use of fish embryos allows for high-throughput screening, providing predictability similar to adult fish and reducing animal testing.

DELIVERIES

The test results are reported in the technical/scientific report, for this test the average lethal concentration (LC50) is determined and the mortality graph is presented.

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Department of Physiology and Behavior

Center of Biosciences - Federal University of Rio Grande do Norte | Brazil

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